Indication: Upper respiratory tract secretions.
Metabolism: Excreted via the kidneys.
Dose adjustments: Use at 50% dose.
Comments: Does not cross blood-brain barrier.
Indication: Upper respiratory tract secretions.
Metabolism: Excreted via the kidneys.
Dose adjustments: Use at 50% dose.
Comments: Does not cross blood-brain barrier.
Indication: Upper respiratory tract secretions.
Metabolism: Excreted via the liver.
Dose adjustments: No dose reductions necessary.
Comments: Does not cross blood-brain barrier.
Avoid
Dose adjustments: Avoid.
Comments: Crosses blood-brain barrier and can cause agitation.
Indication: Agitation.
Metabolism: Predominantly metabolised by the liver.
Dose adjustments: Start with small doses e.g. 1.25 – 2.5mg SC p.r.n. and 5mg/24hr via a syringe driver/pump.
Comments: Increased cerebral sensitivity can occur.
Indication: Pain.
Metabolism: Extensively metabolised in the liver.
Dose adjustments: No change in dose required.
See conversions in Pain chapter.
Comments: Can be given via s.c. syringe driver/pump. Short duration of action limits its use for breakthrough analgesia.
Indication: Pain.
Metabolism: Extensively metabolised in the liver.
Dose adjustments: No change in dose required.
See conversions in Pain chapter.
Comments: Can be given via s.c. syringe driver/pump. Volume limits its use for breakthrough analgesia.