Metabolism: Metabolised by the liver.
Dose adjustments: Avoid or use smallest dose possible in severe renal failure.
Comments: May induce hypotension and tachyarrythmia and is not recommended.
Metabolism: Metabolised by the liver.
Dose adjustments: Avoid or use smallest dose possible in severe renal failure.
Comments: May induce hypotension and tachyarrythmia and is not recommended.
Metabolism: Metabolised mainly by the liver.
Dose adjustments: Reduced doses may be required.
Comments: 1.5mg OD nocte PO/SC.
Metabolism: Ondansetron is metabolised mainly by the liver.
Dose adjustments: Reduced doses may be required.
Comments: Ondansetron 8mg BD PO.
Metabolism: Metabolised by the liver but excreted in the urine and faeces.
Dose adjustments: Reduced doses may be required.
Comments: 6.25mg nocte PO or 2.5mg – 6.25mg SC.
Metabolism: Excreted by the kidneys.
Dose adjustments: Avoid or use smallest dose possible in severe renal failure.
Comments: Increased risk of extrapyramidal side effects in renal impairment.