Preparations and dose equivalence

Doses

Corticosteroid

Approximate equivalent anti-inflammatory dose of corticosteroids*

Dexamethasone 750 micrograms
Prednisolone 5 mg
Hydrocortisone 20 mg

(N.B. this chart dose not reflect the mineralocorticoid actions of these drugs)

Preparations

Corticosteroid

Preparations

Dexamethasone Oral tablets: 0.5mg, 2mg, 4mg, 8mg
Oral soluble tablets: 2mg, 4mg, 8mg
Oral suspension: dexamethasone 2mg in 5ml
Injection: Dexamethasone or dexamethasone phosphate (as dexamethasone sodium phosphate) 3.3mg/ml 1ml and 2ml ampoules, 3.8mg/ml 1ml ampoules
Dosing regimen should be obtained from the individual drug Summary of Product Characteristics
Prednisolone Oral tablets: 1mg, 5mg, 25mg
Soluble tablets: 5mg,
Enteric coated tablets: 2.5mg, 5mg
Suppositories: prednisolone 5mg (Predsol)
Rectal foam: prednisolone (as metasulphobenzoate)
20mg/metered application: 14 applications
Retention enemas:
Predsol retention enema 20mg (as sodium phosphate) in 100ml
Prednisolone retention enema, 20mg (as sodium metasulphobenzoate) in 100ml
Hydrocortisone Oral tablets: 10mg, 20mg
Oral MR tablets: 5mg, 20mg
Mucoadhesive buccal tablets: 2.5mg
Injection: hydrocortisone 100mg/ml 1ml amp, 100mg/2ml 2ml amp, 500mg/5ml 5ml amp

DISCLAIMER

This Guide is intended for use by healthcare professionals and the expectation is that they will use clinical judgement, medical, and nursing knowledge in applying the general principles and recommendations contained within. They are not meant to replace the many available texts on the subject of palliative care.
Some of the management strategies describe the use of drugs outside their licensed indications. They are, however, established and accepted good practice. Please refer to the current BNF for further guidance.
While WMPCPS takes every care to compile accurate information , we cannot guarantee its correctness and completeness and it is subject to change. We do not accept responsibility for any loss, damage or expense resulting from the use of this information.